2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-131271
    Febuxostat impurity 6
    Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat impurity 6
  • HY-N2304
    3-O-Methyl-6β-naltrexone
    		Chemical
    3-O-Methyl-6β-naltrexone is a metabolite of Naltrexone.
    3-O-Methyl-6β-naltrexone
  • HY-109583
    4-Oxofenretinide
    4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9.
    4-Oxofenretinide
  • HY-169768
    (E/Z)-Etherolenic acid
    (E/Z)-Etherolenic acid is a divinyl ether oxylipin and is a metabolite of Linolenic acid.
    (E/Z)-Etherolenic acid
  • HY-135389S1
    Desmethyl Levofloxacin-d8
    Desmethyl Levofloxacin-d8 is deuterium labeled Desmethyl Levofloxacin. Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication[1].
    Desmethyl Levofloxacin-d<sub>8</sub>
  • HY-142217S
    Quetiapine dimer impurity-d8
    Quetiapine dimer impurity-d8 is the deuterium labeled Quetiapine dimer impurity[1].
    Quetiapine dimer impurity-d<sub>8</sub>
  • HY-103252S1
    Monomethyl fumarate-d5
    Monomethyl fumarate-d5 is deuterium labeled Monomethyl fumarate. Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3].
    Monomethyl fumarate-d<sub>5</sub>
  • HY-108263A
    (S)-3-Hydroxy Midostaurin
    (S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML).
    (S)-3-Hydroxy Midostaurin
  • HY-13256AS1
    Desmethyl Erlotinib-d4-1
    Desmethyl Erlotinib-d4-1 (OSI-420-d4-1 (free base); CP-373420-d4-1) is deuterium-labeled Desmethyl Erlotinib (HY-13256A).
    Desmethyl Erlotinib-d4-1
  • HY-126857A
    5-Hydroxyomeprazole sodium
    5-Hydroxyomeprazole sodium is the major metabolite of Omeprazole (HY-B0113). Measuring 5-Hydroxyomeprazole levels in plasma can determine the extent of Omeprazole metabolism.
    5-Hydroxyomeprazole sodium
  • HY-138813R
    N-Desethyl Sunitinib (hydrochloride) (Standard)
    Glycochenodeoxycholic acid sodium salt (Standard) is the analytical standard of Glycochenodeoxycholic acid sodium salt. This product is intended for research and analytical applications. Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC).
    N-Desethyl Sunitinib (hydrochloride) (Standard)
  • HY-N4173R
    8-Oxoepiberberine (Standard)
    p-Dimethylaminobenzaldehyde (Standard) is the analytical standard of p-Dimethylaminobenzaldehyde. This product is intended for research and analytical applications. p-Dimethylaminobenzaldehyde (4-Dimethylaminobenzaldehyde) is an organic compound containing amine and aldehyde moieties which is used in Ehrlich's reagent and Kovac's reagent to test for indoles.
    8-Oxoepiberberine (Standard)
  • HY-135910S
    3,4-Dehydro Cilostazol-d11
    3,4-Dehydro Cilostazol-d11 is deuterated labeled 3,4-Dehydro Cilostazol (HY-135910). 3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol (CLZ; HY-17464). 3,4-Dehydro Cilostazol is used for pharmacokinetic study.
    3,4-Dehydro Cilostazol-d<sub>11</sub>
  • HY-127118A
    Pteropterin monohydrate
    Pteropterin (Pteroyltriglutamic) monohydrate is an active form of folate. Pteropterin monohydrate shows inhibiting effect on tumor growth and has broad anticancer activity.
    Pteropterin monohydrate
  • HY-137386
    2-Oxo-3-hydroxy-LSD
    2-Oxo-3-hydroxy-LSD is a metabolite of Lysergic acid diethylamide.
    2-Oxo-3-hydroxy-LSD
  • HY-12771S2
    O-Desmethyl Mebeverine acid-d6
    O-Desmethyl Mebeverine acid-d6 is deuterium labeled O-desmethyl Mebeverine acid.
    O-Desmethyl Mebeverine acid-d<sub>6</sub>
  • HY-101671R
    S-methyl-KE-298 (Standard)
    S-methyl-KE-298 (Standard)
  • HY-136381
    N-Nitrosoglyphosate sodium
    N-Nitrosoglyphosate sodium is the nitrosamine degradation product and synthetic impurity of glyphosate herbicide.
    N-Nitrosoglyphosate sodium
  • HY-135586R
    Raloxifene N-Oxide (Standard)
    Raloxifene N-Oxide (Standard) is the analytical standard of Raloxifene N-Oxide. This product is intended for research and analytical applications. Raloxifene N-Oxide is a Raloxifene oxidative degradation product.
    Raloxifene N-Oxide (Standard)
  • HY-118620R
    Nortriptyline (Standard)
    Nortriptyline (Standard) is the analytical standard of Nortriptyline. This product is intended for research and analytical applications. Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects. N
    Nortriptyline (Standard)
Cat. No. Product Name / Synonyms Application Reactivity